A. 1000 Hours of Ingredient Screening

We search for ingredients that can deliver the efficacy our products aim to achieve, based on scientific literature and studies to select those with the desired properties.

B. Safety Data Acquisition

We review whether the ingredients can be used in cosmetics. Ingredients often fail this stage if they lack safety data or are only permissible in pharmaceuticals.

C. 5 Rounds of Ingredient Quality Verification

We strive for high-quality ingredients and verify them through a variety of methods.

C1. Non-Destructive Automatic Sampling

A method that automatically collects samples without damaging the product, preparing samples for accurate analysis while maintaining product quality.

C2. Purity Testing

GCMS, LCMS, HPLC, UPLC: These techniques are used to measure the purity of compounds. Each analytical technique is designed to be suitable for different types of compounds. GCMS and LCMS utilize gas and liquid chromatography, respectively, while HPLC and UPLC analyze liquid samples under high pressure to separate and quantify components.

C3. Structural Analysis

NMR, Dispersive X-Ray Diffraction Analysis: NMR is used to elucidate the molecular structure of compounds, and dispersive X-ray diffraction analysis is used to analyze the microstructure of materials, including crystal structure. These methods are essential for accurately determining the molecular and crystal structures of cosmetic ingredients.

C4. Mass Analysis

MALDI TOF, QTRAP: MALDI TOF is used for qualitative analysis to rapidly identify specific molecules in a large sample, and QTRAP is used for quantitative analysis of specific compounds. These technologies measure the precise mass of cosmetic ingredients to confirm their composition and quantify them.

C5. Protein Interaction Analysis

MST and ITC: Microscale Thermophoresis (MST) and Isothermal Titration Calorimetry (ITC) are used to analyze the interaction between proteins and ligands, helping to understand intracellular signaling processes. These methods are crucial for determining how cosmetic ingredients function within cells.

D. 100 Rounds of Efficacy Verification

D1. In Silico Experiments

To minimize animal and cell testing, we utilize computer simulations for molecular dynamic modeling, toxicity prediction, and skin permeability prediction in the early stages of research.

D2. In Vitro Experiments

Once preliminary research data on selected ingredients are compiled, we conduct laboratory tests at the cellular level to truly verify the efficacy of ingredients. These experiments allow for a precise assessment of the effects of ingredients on skin cells.

E. 500 Rounds of Formulating

Based on lab test results, we draft the product formula by combining ingredients in the optimal ratio and concentration. This formulating process considers not only the product's efficacy but also the consumer experience, including texture and feel.

F. Safety and Stability Tests

Once the product formula is determined, safety and stability tests are conducted to evaluate the effects of long-term use and how the product changes under storage conditions. This ensures the product does not cause skin reactions and maintains its quality.